People suffering from Down Syndrome have a characteristic slant of the eyes like mongols (which is why it was also referred to as mongolism at times). The major problem is in the cognitive development of the child with Down Syndrome. Speech and gait may be delayed in such children. Sometimes, speech therapy may be used. People living with Down Syndrome may also have congenital heart disease, short stature, hearing problems and thyroid disorder. Some may develop Alzheimer's and immune deficiencies.
The life expectancy may also be lower. It was only about 25 years in 1980 but now, people with Down Syndrome may live up to 49-50 years or even more if their state of health allows.
Fertility of affected people is very low and even if a person conceives, there are chances that the offspring may also have the disease. It is true for half the incidences of Down Syndrome pregnancies.
However, now facilities are available that make the standard of living quite high for people with Down Syndrome. Programs are offered to develop or refine their cognitive development and to live a fruitful, productive life.