What Is Downs Syndrome?


3 Answers

Katie Harry Profile
Katie Harry answered
Down Syndrome is also referred to as Trisomy 21. The number of chromosomes in humans is 46. In Down Syndrome, a copy of either the whole of chromosome number 21 or part of it is also present. Therefore, people with Down Syndrome have 47 chromosomes in total. A woman is more probable of having a baby with Down Syndrome if she conceives after 40 years of age.
People suffering from Down Syndrome have a characteristic slant of the eyes like mongols  (which is why it was also referred to as mongolism at times). The major problem is in the cognitive development of the child with Down Syndrome. Speech and gait may be delayed in such children. Sometimes, speech therapy may be used. People living with Down Syndrome may also have congenital heart disease, short stature, hearing problems and thyroid disorder. Some may develop Alzheimer's and immune deficiencies.
The life expectancy may also be lower. It was only about 25 years in 1980 but now, people with Down Syndrome may live up to 49-50 years or even more if their state of health allows.
Fertility of affected people is very low and even if a person conceives, there are chances that the offspring may also have the disease. It is true for half the incidences of Down Syndrome pregnancies.
However, now facilities are available that make the standard of living quite high for people with Down Syndrome. Programs are offered to develop or refine their cognitive development and to live a fruitful, productive life.
Aimee Rogers Profile
Aimee Rogers answered
Downs Syndrome affects one in 1,000 babies born today. In the UK there are roughly 60,000 people living with Downs Syndrome and it affects all races, ages and cultures. It is a genetic condition which is passed form the parents to the baby and where most humans have 46 chromosomes, children with Downs Syndrome tend to have 47.

There are different severity levels of the condition and it is impossible to tell from birth how bad the condition will affect the baby. Physically, people with Down's syndrome look a little different to other children and their eyes tend to slant upwards and outwards. The back of the head is also usually quite flat. Many babies with Down's syndrome also have heart defects for example, a hole in the heart.

Mentally people with Down's syndrome can find it a little harder to learn than other people; however this is only usually a mild problem. They are able to do things that ordinary children are able to do such as walk, talk and learn to ride a bike. There is no reason why a person with Down's syndrome cannot lead a healthy, happy life just like anybody else.
Mohamed Saber Profile
Mohamed Saber answered

Down is
caused by all or part of an extra 21 st chromosome.  How much of the
extra chromosome is present could affect severity, as could the way that
person's extra chromosome reacts with the rest of his/her genome. The
generic info on each chromosome codes for proteins, hormones,
neurotransmitters and the like,  as well as having regions that turn on
or turn off other genes. It's a phenomenal balancing act, and science
has barely scratched the surface in terms of our understanding of the
mechanisms and their interplay.
There is another possibility for
less severe Down S: - mosaicism. Usually, all cells in an individual
have the same unique genome - all same chromosomes from the moment of
conception.  So usually a person has Down from conception on.
a person is conceived with 46 chromosomes and at some point very soon
after the fertilized egg stage,  while the are still relatively few
cells,  there is an accident during cell replication/division,  such
that one cell gets am extra 21 st chromosome and its pair Is missing the
2 nd 21 st chromosome.  The one wirh 45 chromosomes is not viable, 
while the othet goes on to replicate cells with 3 of chromosome 21.
Since this happens after there are several. Normal cells,  there is a
mosaic effect where some cells have the usual 2 of 21 st chromosome and
some have 3. Then the severity will be related to the percent of cells
with 3 vs 2 of chromosome 21.

Here's an article about Down syndrome life expectancy:


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