Numbness and tingling are abnormal, yet two of the most common symptoms of multiple sclerosis, which is a chronic disease of the central nervous system. Apart from physiological distress which is very painful, the disease carries with itself a psychological torture because it is always there. There are many possible causes for this, like remaining in the same seated or standing position for a long time, nerve injury which can cause tingling down the back of leg. The other major factors being lack of blood supply to an area, pressure on spinal nerves, lack of vitamins in the body, toxic nerve damage due to prolonged intake/exposure of alcohol, tobacco and lead. Some medical reasons are also responsible, like Diabetes, Stroke, Migraines etc. The most common feeling is like numbness, pins and needles, burning and several itching, tingling, buzzing and vibrating sensations. Home care with proper medical advice is needed in these types of cases. However, in case of emergency situations like pain in neck, forearm, feet, urinating more often, numbness or tingling in legs which worsens when trying to walk, having a rash and when having dizziness, muscle spasm and other unusual symptoms. Medical check-up often includes imagining tests, like CT scan of the head, CT scan of the spine, MRI of the head, MRI of the spine, Angiography, X- Ray and ultrasound of neck vessels. Parasthesias, the other name of the disease, usually gets more severe at night. It is advisable to keep the temperature in the bedroom as cool as possible. Regular and timely consult with the doctor is the best way of keeping this problem at bay.